NITRIC OXIDE (NO) AND DUCHENNE MUSCULAR DYSTROPHY: NO WAY TO GO?

The discordance between pre-clinical success and clinical failure of treatment options for Duchenne Muscular Dystrophy (DMD) is significant.The termination of clinical trials investigating the phosphodiesterase inhibitors, sildenafil and tadalafil (which prolong the second messenger molecule of nitric oxide (NO) signaling), are prime examples of th

Abstract Introduction Acute Stanford type A aortic dissection (ATAAD) is a lethal emergency.However, even with instant surgical repair, early mortality is up to 20%.ATAAD complicated by coronary artery involvement is considered rare Remote Controls but life-threatening because this can cause coronary artery malperfusion which results in acute myoca